JimMcKerrowJames H. McKerrow

Distinguished Professor, Dean of Skaggs School of Pharmacy and Pharmaceutical Sciences and Associate Vice Chancellor of Health Sciences at the University of California San Diego

Director of the Center for Discovery and Innovation in Parasitic Diseases

Dr. McKerrow brings an eclectic and interdisciplinary background to his role as Center Director. He received his PhD from the University of California, San Diego, focusing on peptide chemistry. Instead of the traditional career track to a postdoctoral fellowship, he entered medical school at the State University of New York at Stony Brook. After receipt of his MD, he undertook postgraduate training in internal medicine and pathology, and worked for half a year as a family practitioner at the South Brookhaven Health Clinic in New York. Following board certification in pathology at the University of California, San Francisco, he did a postdoctoral fellowship with Dr. Zena Werb in protease biochemistry and cell biology. He has been a leader in the field of parasite biochemistry and molecular biology since 1985, and was the 2009 recipient of the Gregor Mendel Honorary Medal. Since July 2014, James McKerrow serves as a Dean of the UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences.

PUBLICATIONS

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 Feb 17;12(2):422-434. doi: 10.1021/acschembio.6b01037. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA.

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 Aug;10(8):e0004893. doi: 10.1371/journal.pntd.0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH.

Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 May;12(5):e1005519. doi: 10.1371/journal.ppat.1005519. No abstract available. McCall LI, Siqueira-Neto JL, McKerrow JH.

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May;194(2):180-90. doi: 10.1016/j.jsb.2016.02.015. Epub 2016 Feb 12. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM.

Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14;7(1):77-82. doi: 10.1021/acsmedchemlett.5b00336. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR.

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan;10(1):e0004356. doi: 10.1371/journal.pntd.0004356. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR.

Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrob Agents Chemother. 2015 Dec;59(12):7923-4. doi: 10.1128/AAC.01714-15. No abstract available. Urbina JA, McKerrow JH.

Recognition of the role of Natural Products as drugs to treat neglected tropical diseases by the 2015 Nobel prize in physiology or medicine. Nat Prod Rep. 2015 Dec 19;32(12):1610-1. doi: 10.1039/c5np90043c. Epub 2015 Oct 29. Review. McKerrow JH.

Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015;22(37):4293-312. Review. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A.

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16;10(10):2373-81. doi: 10.1021/acschembio.5b00308. Epub 2015 Aug 13. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG.

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015;9(6):e0003878. doi: 10.1371/journal.pntd.0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C.

Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015;9(6):e0003827. doi: 10.1371/journal.pntd.0003827. Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M.

Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015;6:368. doi: 10.3389/fmicb.2015.00368. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR.

Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar;9(3):e0003588. doi: 10.1371/journal.pntd.0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May;59(5):2666-77. doi: 10.1128/AAC.04601-14. Epub 2015 Feb 23. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS.

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb;9(2):e0003534. doi: 10.1371/journal.pntd.0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA Jr, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA.

Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr;116:76-84. doi: 10.1016/j.antiviral.2015.01.011. Epub 2015 Feb 7. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R Jr, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G.

Increased expression of tumor necrosis factor-α is associated with advanced colorectal cancer stages. World J Gastroenterol. 2014 Dec 28;20(48):18390-6. doi: 10.3748/wjg.v20.i48.18390. Al Obeed OA, Alkhayal KA, Al Sheikh A, Zubaidi AM, Vaali-Mohammed MA, Boushey R, Mckerrow JH, Abdulla MH.

Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 2;22(12):1786-98. doi: 10.1016/j.str.2014.09.015. Epub 2014 Nov 13. Jílková A, Horn M, Rezáčová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M.

Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11;57(23):10162-75. doi: 10.1021/jm501568b. Epub 2014 Nov 25. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM.

4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28;57(16):6989-7005. doi: 10.1021/jm500448u. Epub 2014 Aug 19. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM.

Determinants of disease phenotype in trypanosomatid parasites. Trends Parasitol. 2014 Jul;30(7):342-9. doi: 10.1016/j.pt.2014.05.001. Epub 2014 Jun 16. Review. McCall LI, McKerrow JH.

Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease. ACS Med Chem Lett. 2014 Feb 13;5(2):149-53. doi: 10.1021/ml400403u. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B.

R-Configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi. ACS Med Chem Lett. 2014 Apr 10;5(4):434-9. doi: 10.1021/ml500010m. Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR.

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH.

Trypsin- and chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar;8(3):e2766. doi: 10.1371/journal.pntd.0002766. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvořák J.

Identification of diversity-oriented synthesis derived small molecule, ML341, with cidal activity against Trypanosoma cruzi. 2012 Dec 17 [updated 2013 Nov 07]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Carmody LC, Germain AR, Engel JC, Gut J, Kaiser M, Jewett I, LeQuemen S, Marie JC, Dandapani S, Rodriguez A, Perez JR, McKerrow JH, Palmer MAJ, Munoz B, Schrieber SL.

In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014;58(3):1523-8. doi: 10.1128/AAC.02254-13. Epub 2013 Dec 23. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH.

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. J Med Chem. 2013 Oct 10;56(19):7651-68. doi: 10.1021/jm401067s. Epub 2013 Sep 30. Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR.

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec;57(12):6063-73. doi: 10.1128/AAC.00734-13. Epub 2013 Sep 23. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR.

Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. PLoS Negl Trop Dis. 2013;7(8):e2370. doi: 10.1371/journal.pntd.0002370. Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA.

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013 Jul 11;7(7):e2269. doi: 10.1371/journal.pntd.0002269. Print 2013. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF.

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 9;2:e00712. doi: 10.7554/eLife.00712. Erratum in: Elife. 2013;e01214. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J.

Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis. Curr Med Chem. 2013;20(25):3078-102. Review. Rascón AA Jr, McKerrow JH.

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26;76(4):630-41. doi: 10.1021/np300834q. Epub 2013 Feb 27. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG.

A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May;57(5):2029-35. doi: 10.1128/AAC.01675-12. Epub 2013 Feb 12. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L.

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012;6(12):e1942. doi: 10.1371/journal.pntd.0001942. Epub 2012 Dec 6. Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC.

Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18;51(50):10087-98. doi: 10.1021/bi301305k. Epub 2012 Dec 10. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS.

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. PLoS One. 2012;7(9):e46172. doi: 10.1371/journal.pone.0046172. Epub 2012 Sep 27. Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG.

Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov;9(11):1095-100. doi: 10.1038/nmeth.2182. Epub 2012 Sep 30. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS.

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice. Bioorg Med Chem. 2012 Nov 1;20(21):6423-33. doi: 10.1016/j.bmc.2012.08.047. Epub 2012 Aug 31. dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB.

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6256-60. doi: 10.1016/j.bmcl.2012.07.104. Epub 2012 Aug 15. Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R.

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P.

Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012 Nov;56(11):5450-7. doi: 10.1128/AAC.00643-12. Epub 2012 Aug 6. Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH.

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM.

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun;18(6):956-60. doi: 10.1038/nm.2758. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL.

Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15;287(25):21152-63. doi: 10.1074/jbc.M112.347922. Epub 2012 Apr 26. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P.

Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6(4):e1589. doi: 10.1371/journal.pntd.0001589. Epub 2012 Apr 3. Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH.

A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem. 2012 Mar 2;287(10):7074-83. doi: 10.1074/jbc.M111.313304. Epub 2011 Dec 15. Quezada LA, Sajid M, Lim KC, McKerrow JH.

Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. J Nat Prod. 2011 Dec 27;74(12):2545-55. doi: 10.1021/np200673b. Epub 2011 Nov 30. Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LB, Bjeldanes LF, Crews P.

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct;5(10):e1368. doi: 10.1371/journal.pntd.0001368. Epub 2011 Oct 25. Abdulla MH, Lim KC, McKerrow JH, Caffrey CR.

The Trypanosoma cruzi protease cruzain mediates immune evasion. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC.

Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14;286(41):35770-81. doi: 10.1074/jbc.M111.271304. Epub 2011 Aug 10. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M.

IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct;41(12):1253-62. doi: 10.1016/j.ijpara.2011.06.006. Epub 2011 Jul 23. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P.

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul;5(7):e1253. doi: 10.1371/journal.pntd.0001253. Epub 2011 Jul 19. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH.

Schistosome serine protease inhibitors: parasite defense or homeostasis? An Acad Bras Cienc. 2011 Jun;83(2):663-72. Quezada LA, McKerrow JH.

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei. Chem Biol Drug Des. 2011 Sep;78(3):454-63. doi: 10.1111/j.1747-0285.2011.01156.x. Epub 2011 Jul 14. Mackey ZB, Koupparis K, Nishino M, McKerrow JH.

Cruzain : the path from target validation to the clinic. Adv Exp Med Biol. 2011;712:100-15. doi: 10.1007/978-1-4419-8414-2_7. Review. Sajid M, Robertson SA, Brinen LS, McKerrow JH.

Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR.

An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar;84(3):398-405. doi: 10.1016/j.mimet.2010.12.026. Epub 2011 Jan 22. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH.

IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Sci Transl Med. 2010 Dec 1;2(60):60ra88. doi: 10.1126/scitranslmed.3001500. Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P.

RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19;4(10):e850. doi: 10.1371/journal.pntd.0000850. Stefanić S, Dvořák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR.

The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem. 2011 Jan 7;286(1):429-40. doi: 10.1074/jbc.M110.138313. Epub 2010 Oct 20. Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH.

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem. 2010 Nov 15;18(22):7826-35. doi: 10.1016/j.bmc.2010.09.056. Epub 2010 Sep 29. Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH.

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. PLoS Negl Trop Dis. 2010 Sep 14;4(9). doi:pii: e825. 10.1371/journal.pntd.0000825. Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. J Biol Chem. 2010 Oct 8;285(41):31120-9. doi: 10.1074/jbc.M110.114462. Epub 2010 Jul 30. Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH.

Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med Chem Lett. 2010 Jul 8;1(4):165-9. doi: 10.1021/ml100013s. Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ.

Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Aug;54(8):3326-34. doi: 10.1128/AAC.01777-09. Epub 2010 Jun 14. Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS.

Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. doi: 10.1021/jm100488w. Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK.

A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12. Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM.

Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis. 2010 Apr 6;4(4):e651. doi: 10.1371/journal.pntd.0000651. Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM.

Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis. 2010 Mar 30;4(3):e648. doi: 10.1371/journal.pntd.0000648. Zhang S, Kim CC, Batra S, McKerrow JH, Loke P.

Additional insights on the bastadins: isolation of analogues from the sponge Ianthella cf. reticulata and exploration of the oxime configurations. J Nat Prod. 2010 Mar 26;73(3):365-72. doi: 10.1021/np9005986. Calcul L, Inman WD, Morris AA, Tenney K, Ratnam J, McKerrow JH, Valeriote FA, Crews P.

Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. J Med Chem. 2010 Feb 25;53(4):1763-73. doi: 10.1021/jm901633v. Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA.

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ.

Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar;170(1):37-40. doi: 10.1016/j.molbiopara.2009.11.001. Epub 2009 Nov 13. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR.

Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26;52(22):7192-210. doi: 10.1021/jm900849h. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC.

Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:263-9. McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS.

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR.

Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p. Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.

A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell. 2009 Nov;8(11):1665-76. doi: 10.1128/EC.00123-09. Epub 2009 Sep 11. Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH.

Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. doi: 10.1016/j.bmcl.2009.07.029. Epub 2009 Jul 10. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK.

Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27;52(16):5005-8. doi: 10.1021/jm9009229. Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR.

Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS.

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14;3(7):e478. doi: 10.1371/journal.pntd.0000478. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR.

SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 2;3(6):e449. doi: 10.1371/journal.pntd.0000449. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR.

The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Org Lett. 2009 May 7;11(9):1975-8. doi: 10.1021/ol900446d. Johnson TA, Amagata T, Sashidhara KV, Oliver AG, Tenney K, Matainaho T, Ang KK, McKerrow JH, Crews P.

Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg. 2009 Mar;80(3):416-24. Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, Beatty PR, Harris E.

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009;4(2):e4413. doi: 10.1371/journal.pone.0004413. Epub 2009 Feb 9. Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM.

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM.

The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. J Nat Prod. 2009 Feb 27;72(2):218-22. doi: 10.1021/np800711a. Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P.

Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec;21(6):668-72. doi: 10.1097/QCO.0b013e328315cca9. Review. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P.

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298. Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH.

A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH.

Metal compounds for the treatment of parasitic diseases. J Inorg Biochem. 2008 Oct;102(10):1839-45. doi: 10.1016/j.jinorgbio.2008.05.010. Epub 2008 Jun 4. Erratum in: J Inorg Biochem. 2009 May;103(5):869. Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH.

Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis. 2008 Jul 16;2(7):e262. doi: 10.1371/journal.pntd.0000262. Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH.

Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5860-3. doi: 10.1016/j.bmcl.2008.06.012. Epub 2008 Jun 10. Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR.

Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Mol Biochem Parasitol. 2008 Aug;160(2):129-37. doi: 10.1016/j.molbiopara.2008.05.001. Epub 2008 May 8. Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH.

Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27;283(26):18024-31. doi: 10.1074/jbc.M802133200. Epub 2008 Apr 29. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M.

Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc. 2008 May 21;130(20):6404-10. doi: 10.1021/ja710254m. Epub 2008 Apr 25. Brak K, Doyle PS, McKerrow JH, Ellman JA.

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.

Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32. doi: 10.1021/jm701311r. Epub 2008 Apr 17. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC.

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK.

Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11;283(15):9896-908. Epub 2007 Dec 26. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP.

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorg Med Chem Lett. 2008 Jan 15;18(2):624-8. Epub 2007 Nov 22. Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR.

Proteases in parasitic diseases. Annu Rev Pathol. 2006;1:497-536. Review. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M.

Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6697-700. Epub 2007 Oct 22. González FV, Izquierdo J, Rodríguez S, McKerrow JH, Hansell E.

Host pathogen protein interactions predicted by comparative modeling. Protein Sci. 2007 Dec;16(12):2585-96. Epub 2007 Oct 26. Davis FP, Barkan DT, Eswar N, McKerrow JH, Sali A.

Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb;90(2):345-58. Epub 2007 Sep 8. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH.

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 4;581(22):4260-4. Epub 2007 Aug 9. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K.

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. Epub 2007 Aug 13. Doyle PS, Zhou YM, Engel JC, McKerrow JH.

Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions. Mol Immunol. 2008 Jan;45(2):567-74. Epub 2007 Jul 12. Aslam A, Quinn P, McIntosh RS, Shi J, Ghumra A, McKerrow JH, Bunting KA, Dunne DW, Doenhoff MJ, Morrison SL, Zhang K, Pleass RJ.

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May;15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH.

Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol. 2007;8(4):R65. Jolly ER, Chin CS, Miller S, Bahgat MM, Lim KC, DeRisi J, McKerrow JH.

Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul;154(1):95-7. Epub 2007 Mar 20. No abstract available. Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH.

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun;51(6):2164-72. Epub 2007 Mar 19. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May B

Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul;37(8-9):897-906. Epub 2007 Feb 12. Debnath A, Tashker JS, Sajid M, McKerrow JH.

IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun;37(7):713-24. Epub 2007 Jan 30. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P.

Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan;4(1):e14. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR.

Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006 Dec;2(12):701-10. Review. Renslo AR, McKerrow JH.

The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 1;194(11):1609-16. Epub 2006 Oct 23. Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ.

A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22;281(51):39316-29. Epub 2006 Oct 6. Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH.

A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb;115(2):192-9. Epub 2006 Sep 20. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL.

Characterization of immunoglobulin binding by schistosomes. Parasite Immunol. 2006 Sep;28(9):407-19. McIntosh RS, Jones FM, Dunne DW, McKerrow JH, Pleass RJ.

Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug;387(8):1053-61. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW.

Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11503-8. Epub 2006 Jul 24. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH.

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des. 2006 May;67(5):355-63. Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH.

Giardia lamblia cysteine proteases. Parasitol Res. 2006 Sep;99(4):313-6. Epub 2006 Apr 6. Review. No abstract available. DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH.

Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. J Med Chem. 2006 Mar 23;49(6):2096-102. Rapp M, Haubrich TA, Perrault J, Mackey ZB, McKerrow JH, Chiang PK, Wnuk SF.

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15;16(10):2753-7. Epub 2006 Mar 3. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T.

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec;49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH.

Designing drugs for parasitic diseases of the developing world. PLoS Med. 2005 Aug;2(8):e210. Epub 2005 Aug 30. No abstract available. McKerrow JH.

Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics. 2005 Dec;4(12):1862-75. Epub 2005 Aug 18. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH.

The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9138-43. Epub 2005 Jun 17. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ.

Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul;35(8):895-910. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR.

In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs. Int J Parasitol. 2005 Jul;35(8):851-9. Davies SJ, Smith SJ, Lim KC, Zhang H, Purchio AF, McKerrow JH, West DB.

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr;386(4):339-49. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J.

Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May;35(6):583-9. Epub 2005 Mar 8. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR.

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK.

A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug;136(2):227-42. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S.

IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004 Sep 15;173(6):4020-9. Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA.

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 1;12(19):5203-11. Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC.

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12;279(46):48426-33. Epub 2004 Aug 23. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH.

Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 1;190(3):448-57. Epub 2004 Jul 2. Debnath A, Das P, Sajid M, McKerrow JH.

A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20;279(34):35950-7. Epub 2004 Jun 15. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A.

Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol. 2004 Mar-Apr;106(3-4):158-63. Mahmoudzadeh-Niknam H, McKerrow JH.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 3;47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May;20(5):241-8. Review. No abstract available. Caffrey CR, McKerrow JH, Salter JP, Sajid M.

Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC.

Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Exp Parasitol. 2004 Jan-Feb;106(1-2):59-61. Hernandez DC, Lim KC, McKerrow JH, Davies SJ.

Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec;384(12):1613-8. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC.

Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. Int J Parasitol. 2004 Jan;34(1):27-36. Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH.

Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003;6(4):272-80. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA.

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K.

Developmental plasticity in schistosomes and other helminths. Int J Parasitol. 2003 Sep 30;33(11):1277-84. Review. Davies SJ, McKerrow JH.

Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep;131(1):65-75. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR.

Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug;22(2):155-9. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D.

A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar;71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL.

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20;45(13):2695-707. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE.

CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1537-41. Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE.

Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 5;277(27):24618-24. Epub 2002 May 1. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH.

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30;121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH.

SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30;121(1):49-61. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M.

Invasion of skin by Schistosoma cercariae. Trends Parasitol. 2002 May;18(5):193-5. McKerrow JH, Salter J.

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar;19(3):227-31. Erratum in: Int J Antimicrob Agents. 2005 Jul;26(1):100. Nkemgu-Njinkeng, Joseph [corrected to Nkemngu, Njinkeng Joseph]. Int J Antimicrob Agents. 2005 Nov;26(5):424. Caffrey CR, Schanz M, Nkemngu NJ, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D.

Cysteine proteases of parasitic organisms. Mol Biochem Parasitol. 2002 Mar;120(1):1-21. Review. Erratum in: Mol Biochem Parasitol 2002 Apr 30;121(1):159. Sajid M, McKerrow JH.

Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan;119(1):23-32. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL.

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov;118(1):61-73. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL 2nd, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH.

Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 9;294(5545):1358-61. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH.

Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. FEBS Lett. 2001 Nov 2;507(3):362-6. Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G.

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2759-62. Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC.

Identification, cloning, and recombinant expression of procalin, a major triatomine allergen. J Immunol. 2001 Sep 1;167(5):2694-9. Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N.

Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S63-4. No abstract available. Brinen LS, Que X, McKerrow JH, Reed SL.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Mol Med. 2000 Aug;6(8):660-9. Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ.

Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. J Biol Chem. 2000 Dec 8;275(49):38667-73. Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH.

Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep;7(9):733-42. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH.

A functional proteomics screen of proteases in colorectal carcinoma. Mol Med. 2000 May;6(5):450-60. McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R.

Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi. J Cell Sci. 2000 Apr;113 ( Pt 8):1345-54. Erratum in: J Cell Sci 2000 Jul;113(Pt 14):2638. Garcia CT [corrected to Torres C]. Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH.

The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain. FEBS Lett. 2000 Mar 3;469(1):29-32. Stoka V, Turk B, McKerrow JH, Björk I, Cazzulo JJ, Turk V.

Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28;466(2-3):244-8. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH.

[Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental Chagas disease]. Medicina (B Aires). 1999;59 Suppl 2:171-5. Review. Spanish. Engel JC, Doyle PS, McKerrow JH.

Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Mol Biochem Parasitol. 1999 Oct 15;103(2):171-81. Britton C, Redmond DL, Knox DP, McKerrow JH, Barry JD.

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11015-22. Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, McKerrow JH.

Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. Int J Parasitol. 1999 Jun;29(6):833-7. Review. McKerrow JH.

Blockage of skin invasion by schistosome cercariae by serine protease inhibitors. Am J Trop Med Hyg. 1999 Mar;60(3):487-92. Lim KC, Sun E, Bahgat M, Bucks D, Guy R, Hinz RS, Cullander C, McKerrow JH.

Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg Med Chem. 1999 Apr;7(4):639-44. Review. McKerrow JH, Engel JC, Caffrey CR.

Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. J Biol Chem. 1999 Jun 4;274(23):16249-56. Huete-Pérez JA, Engel JC, Brinen LS, Mottram JC, McKerrow JH.

Do filarid nematodes have a vascular system? Parasitol Today. 1999 Mar;15(3):123. No abstract available. McKerrow JH, Huima T, Lustigman S.

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. Biochem J. 1999 May 15;340 ( Pt 1):113-7. Chan VJ, Selzer PM, McKerrow JH, Sakanari JA.

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei. Exp Parasitol. 1999 Apr;91(4):349-55. Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH.

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors. Bioorg Med Chem. 1998 Dec;6(12):2477-94. Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ.

Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2809-12. Roush WR, González FV, McKerrow JH, Hansell E.

Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. J Mol Biol. 1998;283(1):15-27. Britton C, McKerrow JH, Johnstone IL.

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection. J Exp Med. 1998 Aug 17;188(4):725-34. Engel JC, Doyle PS, Hsieh I, McKerrow JH.

Substrate inhibition of cruzipain is not affected by the C-terminal domain. FEBS Lett. 1998 Jun 12;429(2):129-33. Stoka V, McKerrow JH, Cazzulo JJ, Turk V.

Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J Cell Sci. 1998 Mar;111 ( Pt 5):597-606. Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH.

Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp Parasitol. 1997 Nov;87(3):212-21. Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH.

A simple assay for the detection of native and recombinant protease activity. Anal Biochem. 1997 Aug 15;251(1):121-2. No abstract available. Hagen HE, Kläger SL, McKerrow JH, Ham PJ.

Simulium damnosum s.l.: isolation and identification of prophenoloxidase following an infection with Onchocerca spp. using targeted differential display. Exp Parasitol. 1997 Jul;86(3):213-8. Hagen HE, Kläger SL, McKerrow JH, Ham PJ.

Evaluation of a stage-specific proteolytic enzyme of Schistosoma mansoni as a marker of exposure. Am J Trop Med Hyg. 1997 Jun;56(6):668-73. Ramzy RM, Faris R, Bahgat M, Helmy H, Franklin C, McKerrow JH.

A primitive enzyme for a primitive cell: the protease required for excystation of Giardia. Cell. 1997 May 2;89(3):437-44. Ward W, Alvarado L, Rawlings ND, Engel JC, Franklin C, McKerrow JH.

Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb;65(2):767-73. Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S.

Cytokine induction and exploitation in schistosome infections. Parasitology. 1997;115 Suppl:S107-12. Review. McKerrow JH.

Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation. J Immunol. 1997 Jan 1;158(1):301-7. Leptak CL, McKerrow JH.

Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. J Biol Chem. 1996 Nov 22;271(47):30181-9. Erratum in: J Biol Chem 1997 Feb 14;272(7):4645. Lustigman S, McKerrow JH, Shah K, Lui J, Huima T, Hough M, Brotman B.

Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation. Infect Immun. 1996 Nov;64(11):4706-13. Ritter DM, McKerrow JH.

Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol Biochem Parasitol. 1996 Oct 30;81(2):179-89. Wasilewski MM, Lim KC, Phillips J, McKerrow JH.

Parasitic infections--molecular diagnosis and rational drug design. Biologicals. 1996 Sep;24(3):207-8. No abstract available. McKerrow JH.

Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep;4(9):1421-7. Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL.

Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula. Exp Parasitol. 1996 Jun;83(1):73-82. Ghendler Y, Parizade M, Arnon R, McKerrow JH, Fishelson Z.

Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR. Exp Parasitol. 1995 Nov;81(3):249-54. Hagen HE, Kläger SL, Chan V, Sakanari JA, McKerrow JH, Ham PJ.

The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design. Parasitol Today. 1995 Aug;11(8):279-82. McKerrow JH, McGrath ME, Engel JC.

The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24;247(2):251-9. McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ.

Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. Exp Parasitol. 1995 Feb;80(1):1-7. Brindley PJ, Gam AA, McKerrow JH, Neva FA.

Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice. J Exp Med. 1994 Jul 1;180(1):43-51. Amiri P, Haak-Frendscho M, Robbins K, McKerrow JH, Stewart T, Jardieu P.

Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol. 1994 Jun;78(4):377-85. Mitro K, Bhagavathiammai A, Zhou OM, Bobbett G, McKerrow JH, Chokshi R, Chokshi B, James ER.

Hepatic schistosomiasis. Prog Liver Dis. 1994;12:121-35. Review. No abstract available. McKerrow JH, Sun E.

Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3583-7. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE.

Using scid mice to study parasitic diseases. Lab Anim Sci. 1993 Apr;43(2):136-8. Review. McKerrow JH, Ritter DM.

Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25;268(9):6115-8. Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS.

Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Exp Parasitol. 1993 Mar;76(2):127-33. Hong X, Bouvier J, Wong MM, Yamagata GY, McKerrow JH.

Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Mol Biochem Parasitol. 1993 Mar;58(1):17-24. Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH.

The proteases and pathogenicity of parasitic protozoa. Annu Rev Microbiol. 1993;47:821-53. Review. McKerrow JH, Sun E, Rosenthal PJ, Bouvier J.

Schistosomes and host TNF. Parasitol Today. 1992 Dec;8(12):411-2. No abstract available. McKerrow JH, Ritter D.

Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov;3(11):827-38. Clawson GA, Norbeck LL, Hatem CL, Rhodes C, Amiri P, McKerrow JH, Patierno SR, Fiskum G.

Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992 Aug 25;267(24):17339-46. Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH.

Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae. Exp Parasitol. 1992 Aug;75(1):87-98. Fishelson Z, Amiri P, Friend DS, Marikovsky M, Petitt M, Newport G, McKerrow JH.

Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992 Apr 16;356(6370):604-7. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH.

The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. J Biol Chem. 1992 Apr 15;267(11):7411-20. Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS.

Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Mol Biochem Parasitol. 1992 Apr;51(2):239-49. Ray C, McKerrow JH.

The hemoglobinase of Schistosoma mansoni. R I Med. 1992 Apr;75(4):208-11. Review. No abstract available. McKerrow JH.

Pathogenesis in amebiasis: is it genetic or acquired? Infect Agents Dis. 1992 Feb;1(1):11-4. Review. No abstract available. McKerrow JH.

Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase. Biochemistry. 1992 Jan 28;31(3):806-10. Yuan L, Craig SP 3rd, McKerrow JH, Wang CC.

A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence. Arch Med Res. 1992;23(2):181-2. Reed S, Bouvier J, Hirata K, Que X, Pollack AS, Engel JC, Gillin F, McKerrow JH.

Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry. 1991 Nov 26;30(47):11221-9. Cohen FE, Gregoret LM, Amiri P, Aldape K, Railey J, McKerrow JH.

Recent insights into the structure and function of a larval proteinase involved in host infection by a multicellular parasite. Proc Soc Exp Biol Med. 1991 Jun;197(2):119-24. Review. No abstract available. McKerrow JH, Newport G, Fishelson Z.

High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2500-4. Craig SP 3rd, Yuan L, Kuntz DA, McKerrow JH, Wang CC. Craig

New insights into the structure of a Trypanosoma cruzi protease. Parasitol Today. 1991 Jun;7(6):132-3. No abstract available. McKerrow JH.

Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells. AIDS. 1991 Jan;5(1):93-6. Brown M, Reed S, Levy JA, Busch M, McKerrow JH.

Identification of the secreted neutral proteases from Anisakis simplex. J Parasitol. 1990 Oct;76(5):625-30. Sakanari JA, McKerrow JH.

The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli. J Biol Chem. 1990 Aug 15;265(23):13528-32. Yuan L, Craig SP, McKerrow JH, Wang CC.

Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990 Aug;71(2):199-206. Keene WE, Hidalgo ME, Orozco E, McKerrow JH.

Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Cancer Res. 1990 Apr 15;50(8):2322-9. Apodaca G, Rutka JT, Bouhana K, Berens ME, Giblin JR, Rosenblum ML, McKerrow JH, Banda MJ.

Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. Exp Parasitol. 1990 Feb;70(2):134-43. McKerrow JH, Brindley P, Brown M, Gam AA, Staunton C, Neva FA.

Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Mol Biochem Parasitol. 1990 Feb;39(1):1-8. Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH.

[Direct relation between secretion of proteolytic enzymes and virulence in Entamoeba histolytica]. Arch Invest Med (Mex). 1990;21 Suppl 1:133-8. Spanish. No abstract available. Hidalgo ME, Hernández R, Keene WE, McKerrow JH, Orozco E.

Expression of proteolytic activity by cultures of Trichophyton rubrum. J Med Vet Mycol. 1990;28(2):159-71. Apodaca G, McKerrow JH.

Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989 Dec;27(12):2772-7. Reed SL, Keene WE, McKerrow JH.

Molecular and biochemical studies of the cercarial proteinase of Schistosoma mansoni. Mem Inst Oswaldo Cruz. 1989 Oct;84 Suppl 1:209-10. No abstract available. McKerrow JH.

Regulation of Trichophyton rubrum proteolytic activity. Infect Immun. 1989 Oct;57(10):3081-90. Apodaca G, McKerrow JH.

Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infect Immun. 1989 Oct;57(10):3072-80. Apodaca G, McKerrow JH.

Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4863-7. Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH.

Anisakiasis. Clin Microbiol Rev. 1989 Jul;2(3):278-84. Review. Sakanari JA, McKerrow JH.

Toxocara canis: proteolytic enzymes secreted by the infective larvae in vitro. Exp Parasitol. 1989 Jul;69(1):30-6. Robertson BD, Bianco AT, McKerrow JH, Maizels RM.

Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica. J Immunol. 1989 Jul 1;143(1):189-95. Reed SL, Keene WE, McKerrow JH, Gigli I.

Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15;35(2):177-83. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH.

Evidence for a class of very small introns in the gene for hypoxanthine-guanine phosphoribosyltransferase in Schistosoma mansoni. Nucleic Acids Res. 1989 Feb 25;17(4):1635-47. Craig SP 3rd, Muralidhar MG, McKerrow JH, Wang CC.

Extracellular proteases of Onchocerca. Exp Parasitol. 1989 Feb;68(2):176-85. Lackey A, James ER, Sakanari JA, Resnick SD, Brown M, Bianco AE, McKerrow JH.

Parasite proteases. Exp Parasitol. 1989 Jan;68(1):111-5. Review. No abstract available. McKerrow JH.

Schistosome proteases. Parasitol Today. 1988 Dec;4(12):334-40. McKerrow JH, Doenhoff MJ.

Anisakiasis: revenge of the sushi parasite. N Engl J Med. 1988 Nov 3;319(18):1228-9. No abstract available. McKerrow JH, Sakanari J, Deardorff TL.

A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov;82(5):1560-6. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH.

Cloning of the proteinase that facilitates infection by schistosome parasites. J Biol Chem. 1988 Sep 15;263(26):13179-84. Newport GR, McKerrow JH, Hedstrom R, Petitt M, McGarrigle L, Barr PJ, Agabian N.

Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy. Nucleic Acids Res. 1988 Jul 25;16(14B):7087-101. Craig SP 3rd, McKerrow JH, Newport GR, Wang CC.

Intestinal anisakiasis. A case diagnosed by morphologic and immunologic methods. Am J Clin Pathol. 1988 Jul;90(1):107-13. Sakanari JA, Loinaz HM, Deardorff TL, Raybourne RB, McKerrow JH, Frierson JG.

The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni. Mol Biochem Parasitol. 1988 Mar;28(2):113-20. Amiri P, Sakanari J, Basch P, Newport G, McKerrow JH.

Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis. Infect Immun. 1987 Nov;55(11):2807-15. Resnick S, Pappagianis D, McKerrow JH.

Identification of three stage-specific proteinases of Plasmodium falciparum. J Exp Med. 1987 Sep 1;166(3):816-21. Rosenthal PJ, Kim K, McKerrow JH, Leech JH.

Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease. J Biol Chem. 1987 May 5;262(13):5943. McKerrow JH.

Tissue identification and histologic study of six lung specimens from Egyptian mummies. Am J Phys Anthropol. 1987 Jan;72(1):43-8. Walker R, Parsche F, Bierbrier M, McKerrow JH.

Elastin degradation. Methods Enzymol. 1987;144:288-305. No abstract available. Banda MJ, Werb Z, McKerrow JH.

Preparation of mouse monoclonal anticbodies and evidence for a host immune response to the preacetabular gland proteinase of Schistosoma mansoni cerariae. Am J Trop Med Hyg. 1986 May;35(3):536-43. Pino-Heiss S, Petitt M, Beckstead JH, McKerrow JH.

The major neutral proteinase of Entamoeba histolytica. J Exp Med. 1986 Mar 1;163(3):536-49. Keene WE, Petitt MG, Allen S, McKerrow JH.

Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy. J Biol Chem. 1986 Jan 15;261(2):944-8. Dovey HF, McKerrow JH, Aldritt SM, Wang CC.

Purification and characterization of major extracellular proteinases from Trichophyton rubrum. Biochem J. 1985 Nov 15;232(1):139-44. Asahi M, Lindquist R, Fukuyama K, Apodaca G, Epstein WL, McKerrow JH.

Proteinases from invasive larvae of the trematode parasite Schistosoma mansoni degrade connective-tissue and basement-membrane macromolecules. Biochem J. 1985 Oct 1;231(1):47-51. McKerrow JH, Jones P, Sage H, Pino-Heiss S.

Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1985 Aug;16(2):185-98. Dovey HF, McKerrow JH, Wang CC.

Isolation and characterization of a proteolytic enzyme from the adult hookworm Ancylostoma caninum. J Biol Chem. 1985 Jun 25;260(12):7343-8. Hotez PJ, Trang NL, McKerrow JH, Cerami A.

Schistosoma mansoni: degradation of host extracellular matrix by eggs and miracidia. Exp Parasitol. 1985 Apr;59(2):217-21. Pino-Heiss S, Brown M, McKerrow JH.

Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni. J Biol Chem. 1985 Mar 25;260(6):3703-7. McKerrow JH, Pino-Heiss S, Lindquist R, Werb Z.

Enzyme histochemical comparison of biomphalaria glabrata amebocytes with human granuloma macrophages. J Leukoc Biol. 1985 Mar;37(3):341-7. McKerrow JH, Jeong KH, Beckstead JH.

Heterotopic skin in the uterus. A report of an unusual case. J Reprod Med. 1984 Nov;29(11):837-40. Taylor RN, Welch KL, Sklar DM, McKerrow JH, Creasy RK.

Purine salvage in Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1984 Apr;11:157-67. Dovey HF, McKerrow JH, Wang CC.

Degradation of purified skin keratin by a proteinase secreted from Schistosoma mansoni cercariae. J Parasitol. 1983 Oct;69(5):992-4. No abstract available. Tzeng S, McKerrow JH, Fukuyama K, Jeong K, Epstein WL.

Nuclear magnetic resonance imaging of experimentally induced liver disease. Radiology. 1983 Sep;148(3):743-51. Stark DD, Bass NM, Moss AA, Bacon BR, McKerrow JH, Cann CE, Brito A, Goldberg HI.

Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host. Lab Invest. 1983 Aug;49(2):195-200. McKerrow JH, Keene WE, Jeong KH, Werb Z.

Degradation of extracellular matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomula. Lab Invest. 1983 Aug;49(2):201-7. Keene WE, Jeong KH, McKerrow JH, Werb Z.

Partial purification and characterization of an inhibitor from newborn-rat epidermis with activity against the proteinase of Schistosoma mansoni cercariae. Biochem J. 1982 Dec 1;207(3):479-84. Tzeng S, McKerrow JH, Jeong K, Fukuyama K, Epstein WL.

Hormone receptors in hepatoblastoma: a demonstration of both estrogen and progesterone receptors. Cancer. 1982 Nov 1;50(9):1828-32. Demanes DJ, Friedman MA, McKerrow JH, Hoffman PG.

Elastases and elastin degradation. J Invest Dermatol. 1982 Jul;79 Suppl 1:154s-159s. Review. Werb Z, Banda MJ, McKerrow JH, Sandhaus RA.

Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. Exp Parasitol. 1982 Apr;53(2):249-54. No abstract available. McKerrow JH, Jeong KH.

Neuropathology of progressive rubella panencephalitis after childhood rubella. Neurology. 1982 Feb;32(2):185-90. No abstract available. Townsend JJ, Stroop WG, Baringer JR, Wolinsky JS, McKerrow JH, Berg BO.

Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review. Mech Ageing Dev. 1979 Jul;10(6):371-7. Review. McKerrow JH.

Primary sequence dependence of the deamidation of rabbit muscle aldolase. Science. 1974 Jan 11;183(4120):85. McKerrow JH, Robinson AB.

Sequence dependent deamidation rates for model peptides of cytochrome C. Int J Pept Protein Res. 1974;6(1):31-5. No abstract available. Robinson AB, McKerrow JH, Legaz M.

Rates of nonenzymatic deamidation of glutaminyl and asparaginyl residues in pentapeptides. J Am Chem Soc. 1973 Nov 28;95(24):8156-9. No abstract available. Robinson AB, Scotchler JW, McKerrow JH.

Deamidation of asparaginyl residues as a hazard in experimental protein and peptide procedures. Anal Biochem. 1971 Aug;42(2):565-8. No abstract available. McKerrow JH, Robinson AB.

Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer. Proc Natl Acad Sci U S A. 1970 Jul;66(3):753-7. Robinson AB, McKerrow JH, Cary P.